Based on the difficult problem of water prevention and control technology in inclined mining of fully mechanized mining face, Rongtai Mine 10116 working face of Shanxi Jizhong Energy Group was taken as an example, the comprehensive measure of "preventing, plugging, draining, discharging and intercepting" was adopted to prevent and control water, the geophysical prospecting and drilling was used. Grouting and other technical means greatly reduced the water discharge of the working face during the mining process. At the same time, according to the hydrogeological conditions of the mine, the overlying aquifer of the working face was diverted by drilling to the Ordovician water aquifer on the floor of the working face. The drainage pressure of working face was reduced, and the normal mining face was guaranteed. The technology provided reference for comprehensive prevention and cure water technology of fully mechanized mining face under the same hydrogeological conditions.