With the continuous improvement of the mechanized mining level of coal mines in China, the three-machine equipment of the fully mechanized mining face in mines was continuously upgraded. The volume and weight of the large mining height hydraulic supports were gradually increased. The traditional track and floor transportation of the roadway could not meet the needs of the current high-yield, high-efficiency mine safety production. As a new type of transportation equipment, the monorail crane transportation system was simple in operation, with less personnel, strong adaptability to the roadway, large traffic volume, and strong lifting capacity. It could realize multi-slope, multi-curve and long-distance continuous transportation. The advanced monorail crane transportation system was essential for its supporting operation design. The natural conditions of the mine, the layout of the roadway and the coal mining process, as well as the transportation conditions of the large-scale equipment of the mine were analyzed. Based on the installation of the 151102 fully mechanized mining face in Liuzhuang Mine, the system analysis and design of the running line, conversion yard, running section, support assembly and transportation capacity in the monorail crane transportation system were used to realize the safe and efficient. efficient work under complex geological conditions.