Abstract: Gob-side entry is an important technology for green and efficient mining of coal resources. The mine pressure of gob-side entry in thick coal seam is more intense and unique. No. 2375 Face of Fangezhuang Mine was taken as the engineering background, the stability of surrounding rock of gob-side entry in thick coal seam under different width of coal pillar was simulated and analyzed by using the block discrete element calculation program UDEC, and the reasonable coal pillar width was determined to be 5.5 m under the geological conditions of the mine. The field practice showed that after using the width coal pillar to protect the roadway, the roadway section rate met the production requirements, and the rationality of the design parameters was verified. The relevant research results could provide reference for the design of gob-side entry in thick coal seam under similar occurrence conditions.