Mine water inflow is one of the important indexes to determine the hydrogeological complexity of the mineral deposit, and it is also the main basis for the mine to formulate the mining plan, determine the mine drainage capacity and formulate the water prevention and control measures. Accurate prediction of mine water inflow can prevent the occurrence of mine water damage accidents. At present, there are many calculation methods of water inflow. This paper took Zhangcun Mine as the research object. Based on the full analysis of the composition of the mine water inflow source, the statistical analysis method was used to predict the mine water inflow. The prediction method combined the actual production situation of the mine and the future mining planning, and the prediction accuracy was high.