Cefuroxime sodium powder is obtained by aseptic packaging of cefuroxime sodium sterile raw material. The crystallization process of cefuroxime sodium is optimized. By comparing sodium bicarbonate with sodium isooctanate, the crystallization temperature, crystallization pH value, stirring strength and crystallization system were optimized, the crystalline form of the product is the same as that of the original product, thereby improving the quality and stability of cefuroxime sodium for injection.