The study on the evaluation of the effect of regional exploration and treatment was based on a mine in Huainan, the technical plan and completion of the construction of a long-distance multi-branch directional drilling technique to over-probe the water barrier was introduced at the base of the coal system strata, and the infiltration grouting was used to reinforce and seal the structure and the channel, so as to form an anti-water barrier. During the construction process, the grouting effect was judged and analyzed by various methods, and after the construction was completed, the treatment effect was verified and evaluated by two means.