The main role of mine ventilator is to deliver fresh air to the underground continuously, so the status of mine ventilator needs to be monitored and controlled. The transformation of mine ventilation system of Tenghui Coal Industry was taken as the research object, an intelligent unattended control system was designed. The overall structure design scheme of the ventilation fan control system was introduced, and the design and selection of the system were studied from both hardware and software aspects. Practice showed that the system achieved effective monitoring of the ventilation fan, and the system test showed that the design goal was achieved.