When setting up the roadway along the direction of fracture zone, due to the surrounding rock in the fracture zone, the mining pressure in the roadway was strong and the stress distribution was complicated, so the forced exposure easily leads to the slide and destabilization of the surrounding rock in the roadway, and it is difficult to reach the stable state in the long-term deformation, which brings great difficulty to the roadway support and later maintenance. By analyzing the characteristics of the surrounding rock of the roadway under such special geological conditions, combined with numerical simulation software to further reveal the stress state and deformation damage law of the surrounding rock, a comprehensive support technology plan of over-advanced grouting of the fracture zone, three high support reinforcement technology, and asymmetric reinforcement of the local pre-stressed long anchor cable were developed. The actual observation showed that the fracture zone directional rock support effect was good, the anchor rod was evenly stressed, and the deformation of the roadway surrounding rock was effectively controlled, which ensured the safety of roadway and the stability of the surrounding rock in the later stage.