Research Progress of Quality Evaluation on Oral Traditional Chinese Medicine Preparation
HAN Ji-hong1,LIU Yong-gang2,YAO Dong-yun1,ZHANG Jing1,AN Jing1
1.Hebei Chemical and Pharmaceutical Vocational Technology College, Shijiazhuang 050031, China; 2.NCPC New Drug Research and Development Corporation Ltd., Shijiazhuang 050015, China
Modernization of the quality evaluation of traditional Chinese medicine(TCM) preparations is one of the key areas of modernization of Chinese medicine. The latest progress of quality evaluation on oral TCM preparation was summarized,some new achievements of quality evaluation on oral TCM preparation and valuable experience were introduced. It was pointed out that at present, the mainstream of oral TCM preparation quality evaluation is still mainly based on chemical constituent, such as, index component content assay and fingerprints. Because the complicated composition of TCM, the evaluation method that centering on chemical constituent shows its limitation. A variety of evaluation methods on formulations, efficacy and metabolic have emerged, and have shown some advantages, such as, in vitro evaluation (dissolution determination, bioactivity assay) and in vivo evaluation (serum pharmacochemistry, metabonomic method); Interdisciplinary integration of fingerprints, pharmacodynamics and serum chemistry will help further explain the intrinsic quality and action mechanism of TCM, and gradually shift to effective substance control mode basis.
韩继红,刘勇钢,姚东云,张 静,安 静. 中药口服制剂质量评价研究进展[J]. 煤炭与化工, 2015, 38(1): 37-40.
HAN Ji-hong,LIU Yong-gang,YAO Dong-yun,ZHANG Jing,AN Jing. Research Progress of Quality Evaluation on Oral Traditional Chinese Medicine Preparation. CCI, 2015, 38(1): 37-40.