In order to solve the problem that the traditional selection technology and index are difficult to be applied in the selection of favorable mining target areas of coalbed methane in coal seams with high stress and complex tectonic development, taking the typical regional mine field as an example, based on the analysis of its geological and hydrological conditions, according to the analysis results of coalbed methane recoverability, Kaiyuan and Xinjing mines are determined as the research objects. Through the comprehensive evaluation and analysis of coal seam fracture development, fracture opening and closing, and effective pressure system index, it is concluded that the favorable target areas of Kaiyuan and Xinjing mines are II tectonic unit and fourth exploration area respectively. The research results can guide the optimization of favorable target areas of coalbed methane in high stress and complex tectonic units in the future.