In order to explore the prediction of gas emission and the space-time relationship of gas flow in coal mine working face, so as to improve the level of coal mine safety production. In this paper, firstly, through the laboratory gas experimental parameters, coal seam occurrence and working face layout and other information, the gas emission amount of the protective layer mining working face is predicted and calculated, and the gas emission situation of the adjacent layer is analyzed. Secondly, combined with the ' O ' type circle gas migration channel formed by overburden failure, the distribution law of gas resistance along the tendency and strike is explored, and the characteristics of gas upward uniform flow are revealed. Finally, by studying the space-time relationship of coal seam gas extraction in the protective layer working face, it is found that the gas extraction concentration and flow rate in the range of 8 m in front of the working face to 55 m behind the working face are large, and the gas extraction of cross-layer drilling is the best choice. The research results provide a certain reference for coal mine gas management and safety production, and have certain theoretical and practical significance.