Abstract： After dehydration of GVNE reaction solution, catalyzed by super proton acid, GVNE reacts directly with phenol without crystallization to hydrolyze off the 4-position protective group, thus realizing continuous preparation, thus reducing the solvent loss and energy consumption in the preparation process, and the product prepared is different from the original technology. The reaction mechanism of two kinds of racing reaction was introduced in detail in the continuous reaction method.
白立瑶，张慧荣. 超强质子酸催化下连续法制备7-氨基-3-乙烯基头孢烷酸及一步脱保护反应机理研究[J]. 煤炭与化工, 2023, 46(4): 131-134.
Bai Liyao, Zhang Huirong. Continuous preparation of 7-amino-3-vinylcephalosporanic acid catalyzed by superprotic acid and study on the mechanism of one-step deprotection. CCI, 2023, 46(4): 131-134.
