Optimization of the synthesis process of 1-bromo-3-chloro-2，4-difluorobenzene by the orthogonal design method
Zong Jiancheng1， Liu Feng1， Jiang Tao2
1. Changzhou Liuguojun Vocational Technology College， Changzhou 213025， China； 2. department of Chemical Engineering，Changzhou Institute of Engineering Technology， Changzhou 213164， China
1- Bromo - 3 - chloro-2, 4 - difluorobenzene was synthesized by using 1 - chloro - 2, 6 - difluorobenzene and n-bronusuccinimide (NBS) as raw materials through the bromine reaction. The mole ratio of the materials, the reaction temperature and reaction time were investigated by the single factor experiment,with the yield of the product as index，the best reaction condition was studied through orthogonal test of L16(44)．The optimum reaction conditions is the mole ratio of 1-chloro-2, 6-difluorobenzene to is 1∶1.09, the molar ratio of 1-chloro-2, 6-difluorobenzene to sulfuric acid is 1∶15， the reaction temperature was 0℃ and the reaction time is 4.0 h. Under the optimum synthetic conditions, the yield of the product is up to 90%.
宗建成1，刘 峰1，蒋 涛2. 正交设计法优化3-氯-2, 4-二氟溴苯合成工艺[J]. 煤炭与化工, 2019, 42(10): 135-138.
Zong Jiancheng1， Liu Feng1， Jiang Tao2. Optimization of the synthesis process of 1-bromo-3-chloro-2，4-difluorobenzene by the orthogonal design method. CCI, 2019, 42(10): 135-138.
