New method for synthesizing 4-amino-2-methoxy-5-thiocyano methyl benzoate
Zhang Zhikui1, Liu Hongguo1, Hu Yongqing2, Zhang Baohua3
1. Shijiazhuang Penghai Pharmaceutical Corporation, Shijiazhuang 050600, China; 2. Project Management Office on Utilization Foreign Fund for Agricultural Development, Shijiazhuang 050011, China; 3. College of Chemical Engineering, Shijiazhuang University, Shijiazhuang 050035, China
In order to solve the problem of the production of many by-products and the low utilization of raw materials in preparing a drug intermediate 4-amino-2-methoxy-5-thiocyano methyl benzoate(Ⅰ), using 4-amino-2-methoxy methyl benzoate(Ⅱ) as raw material, in NH4VO3-NH4HSO4-H2O2-NH4Br-NH4SCN-H2O-CH3OH reaction system, the reaction was completed smoothly at room temperature, compound Ⅰ was obtained with 95% yield under the optimized reaction conditions. The materials such as NH4VO3, NH4HSO4 and NH4Br in mother liquor can be reused. The method has the advantages of high yield, no loss of NH4Br and catalyst, no pollution and low production cost.
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