The 2105 transportation roadway of Wangcun Mine was taken as the engineering background, the numerical model was established to analyze the influence of dynamic disturbance on the vibration velocity of the anchorage structure of the roadway and the displacement of the surrounding rock of the roadway, and the optimization design “drilling pressure relief + anchor network cable” joint support program was proposed. Through on-site blasting monitoring, the maximum displacement of the two roadways of the roadway was 34.2 mm. It was verified that the new support scheme can effectively reduce the disturbance of the dynamic load on the roadway and improve the stability, with higher engineering practical value.