Gob-side entry retaining technology has significant advantages in optimizing roadway layout, improving resource utilization and realizing intensive mining. However, in the process implementation stage, it is easy to cause air leakage effect due to structural defects at the joint of flexible formwork wall and roof and the joint of adjacent modules, which aggravates the potential risk of oxidation and spontaneous combustion of residual coal in goaf. In this paper, the 23601 working face of Guandi Mine is taken as the engineering background. Firstly, the gas flow channel is eliminated by closing the air leakage path of the U-shaped ring in the goaf. Secondly, the grouting pipeline is preset inside the flexible formwork wall to implement directional filling ; finally, a multi-parameter real-time monitoring system is established for dynamic early warning of the whole process, and a three-in-one fire prevention and extinguishing technology system is constructed. The application results show that the oxygen concentration in the goaf decreases continuously with the advance of the working face, and the peak concentration of CO in the monitoring period is only 86×10-6, which is significantly lower than the safety value. Through the effective combination of spatial positioning technology and active prevention and control measures, the precise positioning and targeted treatment of fire source location are successfully realized, which fundamentally eliminates the risk of spontaneous combustion of coal seam and ensures the safe mining operation of fully mechanized mining face under complex geological conditions.