In order to extend the service life of the mine, the coal resources overlaid by the mine industrial site are planned to mine in Handan Niuerzhuang Mining Company. The main drainage system currently used in the mine was located within the protection coal pillar range of the mine industrial site. Mining the coal pillar resources of the industrial square was bound to cause serious damage to the main drainage system roadway, resulting in the mine unable to drain normally. The mine industrial square underground production system, industrial site coal pillar resource mining planning were comprehensive analyzed. Through the system optimization, the No.2 horizontal drainage pump room was relocated to liberate overburden resources, ensure the integrity of the mine drainage system and provide a security guarantee, achieving the purpose of saving investment, shortening the construction period, the greatest degree of liberation of industrial site overburden coal resources.