In order to solve the traditional slime water treatment process, the excessive use of flocculant caused waste of drugs and poor flocculation effect. Excessive drug loading also increased the viscosity of the slime system, which caused the accumulation of various ions and the quality of the effluent water and a series of questions. The effect of flocculant type, molecular weight of flocculant and amount of flocculant on the treatment of slime water were studied, the optimal treatment condition was got. By adding inorganic non-metal ions, the flocculant and inorganic non-metal ions to matching slime water treatment effects were discussed. The test results showed that under the action of anionic flocculant, the slime floc particle size was large and the sedimentation speed was fast, and the supernatant had a high transmittance; the amount of flocculant increased, the floc particle size was large, and the sedimentation speed was fast, but the supernatant liquid transmittance value was small.