A synthesis method for 4-formamidoantipyrine using methyl formate and formic acid as two acylating reagents in a staged reaction with stepwise temperature increase were provided which reduce the formation of oxidative impurities and improves product quality.  The effects of different conditions such as the ratio of methyl formate to formic acid in each stage, reaction temperature, and reaction time on the purity of 4-formamidoantipyrine were separately investigated. The optimal process conditions are as follows: Methyl formate stage: the molar ratio of 4-aminantipyrine to methyl formate is 1∶0.14, with a reaction time of 2 h at 40 ℃, achieving a conversion rate of 47.8%; Formic acid stage: the molar ratio of residual 4-aminantipyrine to formic acid is 1∶0.17, with a reaction time of 2 h at 80 ~ 85 ℃, resulting in a 4-formamidoantipyrine content of 99.1%. The efficient synthesis of 4-formamidoantipyrine through precise control of the composition of acylating reagents and reaction parameters were achieved.