Abstract： This paper presents a method for the determination of residual solvents in metamizole sodium, which can be used for the determination of residual formaldehyde in metamizole sodium. The detection method is as follows: DB-WAX column, FID detector, column temperature 80 ℃, injector temperature 200 ℃, detector temperature 350 ℃, under programmed heating condition, calculation by external standard method. The results showed that there was a good linear relationship between formaldehyde concentration at 50.0 ~ 300.0 mg/mL, RSD was less than 5% , R2 was 0.999 8, the peak shape is good, the separation of solvent peak and formaldehyde peak is good, the method is simple, rapid, accurate and sensitive, and can be used for the quantitative determination of Formaldehyde content, thus ensuring the quality improvement of analgin.
王晓凤，王莉莉，焦银蕾，康 倩，李焕君，张晓灿，张 云，王 丽，何晓晨，刘晓莲，马宁宁. 安乃近残留溶剂甲醛的气相色谱检测法[J]. 煤炭与化工, 2022, 45(5): 143-145.
Wang Xiaofeng， Wang Lili， Jiao Yinlei， Kang Qian， Li Huanjun， Zhang Xiaocan， Zhang Yun， Wang Li， He Xiaochen， Liu Xiaolian， Ma Ningning. A gas chromatography detection method of Anna near residual solvent formaldehyde. CCI, 2022, 45(5): 143-145.
