Aiming at the problems of complex surrounding rock conditions and difficult support of roadways in the section of subsidence pillars in the return air roadway of No. 2-106 working face of Huobao Ganhe Mine, through field investigation and analysis of surrounding rock condition and supporting principle of roadway, combined with geological condition of 2-106 working face, the combined support scheme of "anchor mesh cable beam+ single anchor cable+ shotcrete" was put forward, and underground field test was carried out. The results showed that the surrounding rock stability of the roadway in the subsidence column section was better guaranteed, the deformation and destruction of the roadway were controlled, and remarkable economic and social benefits were achieved.