Aiming at the problem that the unified setting of ground grouting parameters led to the discrete transformation effect under the condition of strong permeability and high fracture connectivity of Ordovician limestone aquifer in deep coal seam mining, the intelligent optimization research of grouting parameters was carried out. Based on the field grouting monitoring data, the extraction methods of characteristic quantities including ΔV/ΔP and dP/dt were constructed, and the parameter-response mapping model was established. Under the constraints of pressure, flow and water-cement ratio, parameter inversion and zoning matching were carried out, and a dynamic control strategy in the construction stage was formed. The engineering application results showed that the optimized parameters could control the slurry migration path and improve the fracture filling state. The pumping test and mining monitoring data reflected the permeability characteristics and water volume response changes. A quantitative optimization method of grouting parameters for heterogeneous aquifers was formed.