In view of the phenomenon of large mining height, wide mining width, long strike and high in-situ stress of overlying strata in fully mechanized top coal caving in extremely thick coal seam of North China coalfield in western Inner Mongolia, taking Tangjiahui Coal Mine of Huainan Mining Group as an example, by comparing and analyzing the development of roof microseism events in roof cutting and non-roof cutting mining faces, the response law of microseism monitoring in the mining process of Carboniferous coal seam in thick main mining was studied, and the time-space-energy comprehensive response characteristics of microseism monitoring were analyzed. The results showed that for the uncut roof working face of No.6 coal seam in Tangjiahui Coal Mine, the disturbance range of roof strata monitored by microseism monitoring was large, which could reach 15 ~ 20 times of mining height. In the working face with roof cutting and pressure relief measures, the height of overburden failure monitored by microseismic monitoring was about 12 times of the mining height, which had obvious effect on the control of roof strata pressure in extremely thick coal seam mining. Roof cutting and pressure relief could build a relatively low stress area in advance to avoid dynamic disasters caused by abnormal mine pressure.