In order to ensure the smooth mining of No.8472 Face in Yangdong Coal Mine, the effectiveness of the combined means of geophysical prospecting and drilling contorl in the complex geological structure development of coal mine and the high pressure area of Ordovician limestone water was explained. No.8472 Face of Yangdong Mine adopted multiple means such as geophysical exploration and regional control to comprehensively explore whether there was water-bearing structure development in the working face and deep part. Three geophysical exploration methods including transient electromagnetic, electrical sounding and channel wave earthquake, were used to detect the working face and the half space below the working face. The regional control was mainly aimed at the Daqing limestone section. The safe mining of the working face was ensured. It was proved that the following method could fully reduce the water outburst coefficient and greatly improved the safety factor of working face mining under complex geological conditions. which included taking targeted geophysical prospecting to control the hidden dangers of water-bearing geology within 80 m space around the working face, drilling to control the deep aquifer under the working face, and transforming the aquifer into an aquifuge.