In order to eliminate the risk of water outburst in the abnormal area of the working face in the thick coal seam with thin aquiclude, a joint exploration and control system was established. Through the exploration and analysis of the pressure status of No.6 coal seam in Tangjiahui Mine and the threat of water outburst from the floor, the ground targeted precise control and underground directional drilling grouting were used to reinforce the aquiclude, and the microseism monitoring technology was used to monitor the risk of water outburst in the abnormal area during the mining process in real time. The results showed that the proportion of microseism events in the depth of 30 m below the floor of 6 coal seam was only 1.5 %. The microseism events in the deep aquifer were sporadic and there was no aggregation trend in the vertical direction, indicating that the Y6 abnormal area was effectively controlled, which could basically ensure that the mining in the working face was not threatened by the water disaster in the floor.