2条新型抗菌肽的构效关系研究
刘立伟，朱正煜，张荐益，高腾超
华北理工大学 迁安学院，河北 迁安 064400
Study on structure-activity relationship of two novel antibacterial peptides
Liu Liwei， Zhu Zhengyu， Zhang Jianyi， Gao Tengchao
Qian'an College， North China University of Science and Technology , Qian'an 064400, China
摘要 以蜂毒肽mastoparan（简称MP）和孤蜂毒液肽Anoplin为母体，通过Leu、Lys连接起来组成具有25个氨基酸残基的2条新型抗菌肽AM-1、AM-2。实验研究表明，该新型抗菌肽的体外抗肿瘤明显高于母体，对正常细胞（NIH-3T3）的杀伤力低于肿瘤细胞，说明其具有一定的选择性毒性，但是其溶血率却较高。
关键词 ：
蜂毒肽 ,
孤蜂毒液肽 ,
抗菌肽 ,
构效关系
Abstract ：Taking mastoparan(MP) and Anoplin as the parent, two novel antimicrobial peptides AM-1 and AM-2 with 25 amino acid residues were formed by linking Leu and Lys. The experimental results show that the antitumor activity of the new antimicrobial peptide in vitro is significantly higher than that of its parent, and its lethality to normal cells (NIH-3T3) is lower than that of tumor cells, indicating that it has certain selective toxicity; but its hemolysis rate is higher.
Key words ：
mastoparan
Anoplin
antibacterial peptides
structure-activity relationship
作者简介 : 刘立伟（ 1984— ），女，河北唐山人，讲师。
[ 1 ] Wei Zhang, Jia Li, Liwei Liu, et al. A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic efficacy against cancer and diminished toxicity in mice[ J ].Peptides, 2010 ( 31 ): 1 832 - 1 838.
