In order to study and finalize the pharmaceutical preparation of Gliclazide modified-release tablets, improve its clinical application, and provide better service for patients,the rate of dissolution over predefined periods of time were tested,and the optimal formulation and preparation of the tablets were determined.The results showed that Gliclazide modified release tablets in compliance was prepared with hydroxypropyl methylcellulose E50, silicon dioxide and lactose as main excipients, and through the following process steps which were wet granulation, fluid bed drying, granular sizing, lubrication and compaction.The formulation and preparation process was straightforward, reliable, and could be use for manufacturing the tablets.