In order to govern E12605 Spontaneous combustion hidden danger of fully mechanized working face in Cuijiazhai Mine, adopting the inhibitor for the spraying agent, sealing on nitrogen inerting, playing fire drill three-phase foam injection, injecting efficient expansion flame retardant—MIR and a series of comprehensive control measures, which eliminated the fire hidden danger, the result showed that all kinds of technical measures of the fire preventing and extinguishing got good result in fully mechanized working face and ensured the safe stoping of the working face. Meanwhile, corresponding countermeasures were put forward from technology and management in future accident precaution.