In order to evaluate the industrial applicability of the KC-103S presulfided sulfur-resistant shift catalyst in the shift unit of a residuum-to-hydrogen production plant, a quantitative analysis of operational data from a specific residuum-to-hydrogen production unit was conducted. Under approximately 90% load with dual gasifiers and about 103% load with a single gasifier, the CO (dry basis) volume fraction at the shift reactor outlet remained stable at 1.0% to 0.65%, consistently exceeding the design target of 1.0%. The system pressure drop remained below 40 kPa over the long term, with no abnormal fluctuations or significant powdering or clogging observed during operation. Through factory presulfiding and passivation, the shift unit achieved online-free startup, reducing the commissioning cycle by 3 to 5 days, saving tens of tons of CS2 consumption while mitigating safety and environmental risks. The KC-103S presulfided sulfur-resistant shift catalyst demonstrated high and stable CO conversion performance in the unit, meeting the requirements for long-term stable operation of the residuum-to-hydrogen production plant. It also provided valuable engineering reference for catalyst selection in similar types of units.