The gas disaster of Panjiang mining area is serious. In order to optimize the problem of long time and large amount of engineering in regional outburst prevention measures, a progressive regional outburst prevention technology with directional long boreholes along the seam is proposed. The drilling equipment with directional function is used to control the extraction of the return air lane or transportation lane in the upper and lower sections of the upper and lower sections by the directional long boreholes along the seam, so as to reduce the cost of regional outburst prevention measures and realize ' one hole two elimination '. The engineering test results show that the construction depth and extraction effect of the upward bedding directional long borehole are better than those of the downward bedding directional long borehole. The construction depth of the upward bedding directional long borehole is 174-203 m, and the extraction concentration of the main pipe is about 46 %. The gas content of the coal seam is reduced to 5.23 m3/t, and the outburst elimination is achieved.