Geological structure was an unfavorable factor restricting the mining of coal resources and the safe excavation of roadways. When the roadway was excavated through the geological structure, it was affected by factors such as broken surrounding rock, joint and fracture development. The roof support of the roadway was difficult, the super-high phenomenon was frequent, and the watering and coal wall crushing appeard, which brought potential safety hazards to production. In order to ensure the safe, high-yield and high-efficiency excavation of the roadway, the advanced pre-grouting reinforcement was carried out in No.5 coal preparation roadway of Yushupo Mine. The field application effect was remarkable, which ensured the stability of the surrounding rock structure, realized the safe production through the fault zone, solved the influence of passing through geological structure on the tunneling, reduced the invalid footage, and achieved the goal of high yield and high efficiency.