In order to solve the problem of non-reverse airflow in the newly-introduced wind shaft of Dongpang Mine, the network analysis of the four-in and three-out mixed ventilation system of Dongpang Mine was carried out, and the wind pressure balance law was used to determine the influence of the new wind shaft. Based on the key factors verified by the anti-wind test, a feasible and effective response measures were finally worked out, which solved and improved the efficiency of the new wind shaft, and made it have perfect anti-wind and disaster resistance.