7-ACA, 7-Aminocephalosporanic acid, is an intermediate in the synthesis of β-lactam antibiotics. Cephalosporin C is obtained by biological fermentation, and then transferred to 7-ACA which contains two kinds of residual solvent acetone and isopropanol by enzymolysis. The content of residual solvent acetone and isopropanol were measured by gas chromatographic method. This method shows good separating effect and is simple to conduct with samples separating in a short time,and can be applicable to determination of residual solvents of 7-ACA.
刘 倩. 7-ACA中丙酮和异丙醇2种残留溶剂测定方法[J]. 煤炭与化工, 2016, 39(3): 105-107.
Liu Qian. Determination method of two residual solvents acetone and isopropanol in 7-ACA. CCI, 2016, 39(3): 105-107.
