Study on Synthetic Process of 4- Bromo -2,6- two f - three Difluoro Methoxy Benzene
QI Su-zhong1，SHI Jun-jie2，CHEN Ya-peng2，LI Jing2
1.Hebei Weiyuan Biological Chemical Limited by Share Ltd., Shijiazhuang 050031 ,China; 2.Department of Chemistry and Environmental Engineering，Hebei Chemical and Pharmaceutical College, Shijiazhuang 050026,China
A synthetic method of 4- bromo -2,6- two f - three difluoro methoxy benzene was provided using 3,4,5- three fluorine bromine as raw material through substitution reaction, dealkylation reaction, three difluoromethylation reaction, finally the target product 4-bromo -2,6- two fluorine bromine difluoro methoxy - three benzene was got. This method had the characteristics which were the synthetic process was simplified, synthetic technology was reasonable, synthetic steps were shorter, the yield of target product was high, the cost was low, the synthetic process was conducive to large-scale industrial production etc.. Therefore, the synthesis method was suitable for large scale preparation of target compounds.
齐素忠1， 师俊杰2，陈亚鹏2，李 璟2. 4-溴-2,6-二氟-三氟甲氧基苯的合成工艺研究[J]. 煤炭与化工, 2013, 36(5): 78-80,124.
QI Su-zhong，SHI Jun-jie，CHEN Ya-peng，LI Jing. Study on Synthetic Process of 4- Bromo -2,6- two f - three Difluoro Methoxy Benzene. CCI, 2013, 36(5): 78-80,124.
