氨噻二唑肟乙酸的合成工艺改进
陈 1 ，孙雅博1 ，陈 慧1 ，魏顺金2 ，李 璟1
1.河北化工医药职业技术学院，河北 石家庄 050026； 2.河北省化学工业研究院，河北 石家庄 050031
Improvement on the Synthesis of 2-（ 5-Amino-1,2,4-thiadiazol-3-yl ）- 2-（ methoxyoimino )a cetic acid
CHEN Ying1 , SUN Ya-bo1 , CHEN Hui1 , WEI Shun-jin2 , LI Jing1
1. Hebei Chemical and Pharmaceutical College, Shijiazhuang 050026, China; 2. Hebei Chemical Industry Research Institute,Shijiazhuang 050031,China
摘要 研究了第4代头孢菌素的关键中间体7位侧链酸——氨噻二唑肟乙酸衍生物的合成工艺。考察了多种催化剂在不同浓度条件下对水解反应的影响，结果表明适宜的水解反应催化剂为LiOH，同时使用氧化剂和相转移催化剂可使收率大幅提高，收率达到80%，产品纯度可达97%，质量明显优于其他方法。本工艺原料易得，操作简单，收率提高，产品质量优异，适合工业化生产。
关键词 ：
氨噻二唑肟乙酸 ,
头孢菌素 ,
中间体 ,
合成
Abstract ：The synthesis process of ammonia thiadiazole oxime acetic acid,the fourth-generation cephalosporins key intermediate 7 side chain acid was studied. The variety of catalyst under the condition of different concentrations on the influence of the hydrolysis reaction were examined. The results showed that a suitable hydrolysis catalyst was LiOH, using both oxidant and a phase transfer catalyst could get yield a substantial increase, yield of 80%, purity of 97%, quality was superior to other methods. This process had the chanacteristics of readily available raw materials, simple operation, improving the yield, excellent product quality and being suitable for industrial production.
Key words ：
2-（5-amino-1,2,4-thiadiazol-3-yl）-2-（methoxyoimino)acetic acid
cephalosporin
intermediate
synthesis
作者简介 : 陈 （ 1983— ），女，辽宁沈阳人，讲师。E-mail：chengyingsf@163.com
引用本文:
陈 ，孙雅博，陈 慧，魏顺金，李 璟. 氨噻二唑肟乙酸的合成工艺改进[J]. 煤炭与化工, 2013, 36(5): 76-77.
CHEN Ying, SUN Ya-bo, CHEN Hui, WEI Shun-jin, LI Jing. Improvement on the Synthesis of 2-（ 5-Amino-1,2,4-thiadiazol-3-yl ）- 2-（ methoxyoimino )a cetic acid. CCI, 2013, 36(5): 76-77.
链接本文:
http://www.mtyhg.com.cn/CN/ 或 http://www.mtyhg.com.cn/CN/Y2013/V36/I5/76
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