With the rapid development of chemical industry, the production of chemicals including hazardous chemicals are getting lager, strengthening the safety management is particularly important. The existing management status of hazardous chemicals in production, operation, transportation, storage, use etc. and the problems that exist in safety management of hazardous chemicals were analyzed. And also countermeasures to improve the safety management of dangerous chemicals warehouse were proposed, namely the layout of dangerous chemicals industry should be adjusted reasonably, great importance should be attached to the management of major hazard sources and emergency rescue, the early warning system and supervision system should be established and improved.