Cefoxitin is the second generation head molds semisynthetic antibiotics, because of its β-lactamase stability,so it  is widely used and has huge market potential.Some snythetic methods of cefoxitin were introduced with 7-ACA, 7-MCA and deacetyl 7-ACA  as raw materials, the advantages and disadvantages of each method are compared and evaluated. The synthetic method with 7-ACA as raw material had advantages which were easily-accessible raw materials, short process, low cost, high yield, more suitable for mass production.