To study the safe offset of coordinated co-mining of upper and lower coal seam working faces with large coal seam spacing and not belonging to the category of close-range coal seams, taking the co-mining working faces of No. 5 and No. 2 coal seams in Jiaojiazhai Coal Mine as the research object, the relationship between the spacing of upper and lower coal seams and the "three belts" of the collaborative mining roof was analyzed, and three structural models were proposed; The stress disturbance of co-mining in the working faces of the upper and lower coal seams was studied. The heights of the sag zone and fracture zone in the mining of the working faces of the upper and lower coal seams were theoretically calculated, and the reasonable strike offset of the co-mining working face was determined. The FLAC3D numerical calculation model was established to analyze the stress distribution and displacement law of the surrounding rock under the conditions of dislocation distances of 10, 40, 70, 100, 130 and 160m. The research results show that: The distance between the No. 5 coal seam and the No. 2 coal seam, which is 72.4m, is greater than the collapse zone of the working face of the No. 5 coal seam and smaller than its fracture zone. Theoretical calculation shows that the reasonable offset distance for the coordinated simultaneous mining of coal seams No. 5 and No. 2 is 90 meters. As the offset distance between the upper and lower coal seam working faces decreases, the peak value of the advanced support prepressure in the lower coal seam working face increases.