Based on the background of strengthening support of concentrated roadway in soft and fractured zone of Zhaozhuang No. 2 Shaft and the development of roof fissures of concentrated roadway through on-site borehole peeping, the design parameters of coupling support was optimized, the coupling support technology suitable for the influence of geological structure on regional concentrated roadway was put forward. The engineering practice proved that the supporting system effectively controlled the deformation and destruction of surrounding rock after adopting the coupling support method of anchor cable reinforcement and grouting reinforcement. After grouting reinforcement treatment for about 90 d, the deformation speed was basically zero, which met the needs of long-term use of roadways, and provided reinforcement under such geological conditions.