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| Research on methyl esterification of gulonic acid in a microchannel reactor |
| An Weihong, Lu Xiaoming |
| CSPC Weisheng Pharmaceutical（Shijiazhuang）Corporation Ltd., Shijiazhuang 050035, China |
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Abstract In order to find an efficient synthesis process of methyl gulongate, promote the vitamin C raw material production industry to achieve energy conservation and green development. In this paper，methyl 2-keto-L-gulonate was synthesized in a microchannel reactor using 2-keto-L-gulonic acid and methanol as raw materials and concentrated sulfuric acid as catalyst. The effects of material ratio, catalyst dosage, reaction temperature and residence time on product content and conversion rate were investigated, and the technological parameters were optimized. The results show that when the reaction temperature is 85℃, the amount of concentrated sulfuric acid as catalyst can be reduced to 0.2%, and the reaction time can be shortened to 90 minutes；Compared with the traditional kettle synthesis process, the new process can reduce the amount of catalyst, eliminate the reaction amplification effect and temperature fluctuation, shorten the reaction time, and improve the safety of the process.
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