Methane oxidation is a critical technology for producing synthetic ammonia, widely applied in industrial production due to its high economic efficiency and environmental friendliness. However, the methane oxidation method for ammonia synthesis faces issues such as catalyst deactivation, reaction condition fluctuations, and by-product formation anomalies, significantly affecting process stability and output efficiency. The key anomalies in the methane oxidation ammonia synthesis process was summarized, the causes and resulting process bottlenecks were analyzed. Based on the analysis, a series of optimization measures was proposed, including controlling reaction conditions, improving catalyst performance, and optimizing reactor design, providing feasible solutions for enhancing process efficiency and product purity. Additionally, the potential for integrating advanced monitoring technologies to further stabilize the process were discussed, thereby the sustainable development of the industry were ensured.