With the depth of coal seam mining increases, the construction borehole in the deep area is affected by the conditions of high water pressure, earth pressure and high water temperature, which makes it difficult to block the drilling process. In this paper, Fengfeng Mine Xintun mining area of -600 level exploration hole closure was taken as an example, by analyzing the drilling site construction conditions, the water location, borehole structure, to develop scientific and rational management programs, and then the high pressure, large-flow borehole construction and sealing technology were summed up, providing technical reference for blocking borehole under similar conditions.