Ascending mining was common in mining process of coal mine. In order to analyze feasibility of ascending mining in J2501 working face of a mine, FLAC numerical simulation method was used. Three-dimensional numerical simulation model was built according to geological and mining conditions of J2501 working face so as to analyze deformation features of overlying strata after mining. The results showed that the influence of 7 coal seam mining to 6-1 coal seam stress state was performed mainly on depressurization, the maximum subsidence of coal seam was 2.2m with intact integrity and no obvious fracture. Therefore, ascending mining in 6-1 coal seam of D4 mining area of a mine was feasible.