Liquid oxygen gasification station is one of the most commonly used methods of oxygen supply in the factory production in recent years, the advantages and disadvantages of the design will directly effect the smoothly of the oxygen supply, and thus relate to the stability of the whole factory production. The typical technological processes of the oxygen gasification station were briefly introduced , and as the oxygen reconstruction project of steel structure processing factory an example, the design points about calculation process of the oxygen gasification station, equipment selection calculation and layout, process piping and the material selection of attachment were discussed in detail, the security should be focused on in the design process, finally, several important points which be paid attention to in the actual production and operation of the gasification station were put forward.