At present, emission pollution of the lead in atmosphere is increasingly serious. It is very important for the detection of lead in human body, the two element analyzer is an important instrument for detecting lead in human blood. The principle of the measurement and calibration method of the two element analyzer were introduced. It is pointed out that prevention and detection of lead poisoning are very important. Blood test is the most reliable method, the accuracy of the analysis results can be ensured, and it is an important guarantee for the blood lead test in human body.