The ozone oxidation method was used to treat the simulated phenolic waste water, the processing efficiency of ozone oxidation method was studied. Initial phenol concentration, initial pH value of solution，the amount of ozone inflow, and dosage of catalyst etc. that effect the removal rate of phenol were analyzed in detail. The results show that the initial pH of the waste water and the amount of ozone inflow had a great influence on the removal of phenol in waste water and provide a basis for dealing with phenolic wastewater with ozone.