BThickness of float coal in Changcun Mine goaf was big, which provided material conditions for coal spontaneous combustion. To prevent fire accidents, the inhibitor agent fire-fighting, nitrogen injection, preventive grouting and coal seam water injection measures such as combination of comprehensive measures were adopted to prevent coal spontaneous combustion area. Through the tube monitoring system analysis, after the comprehensive prevention measures, in the region of 10301 working face CO concentration is low, without CO concentration overrun alarm in upper corner, which greatly reduced the chances of the fire accident and ensured safe mining face recovery.