To accurately determine the chloride ion content in sulfide-containing wastewater from coal chemical processes and solve the interference of sulfides in the determination process, mohr's method (silver precipitation titration) was took as the core and the effects of water sample pretreatment conditions and titration parameters on the determination results were systematically investigated. By optimizing pretreatment parameters such as the type of acidic medium, sulfuric acid dosage, and heating time, a targeted interference elimination method was established. The results show that the method features simple operation, rapidity and high efficiency, and its accuracy meets the requirements for coal chemical wastewater detection. It can effectively eliminate sulfide interference and provide technical support for the routine detection of chloride ions in sulfide-containing wastewater from coal chemical processes.