Aiming at the control problem of large deformation and failure of surrounding rock in gob excavation of deep island strip filling face during mining, No.11235 transportation roadway of Xingdong Mine was taken as the engineering background and conducts a complete system research on the stability control of surrounding rock in gob excavation by integrating field measurement, theoretical modeling, numerical simulation and engineering practice and other multidimensional research methods. According to the field investigation, the characteristics of large deformation and failure of surrounding rock in gob-side entry driving in deep isolated island were analyzed, and its failure mechanism was systematically expounded. Three-dimensional numerical models based on different mechanical constitutive models were constructed, and the stress distribution characteristics and evolution law of gob-side entry driving after driving and during mining were analyzed. Combined with the results of numerical simulation and theoretical analysis, combined with the technical parameters of surrounding rock support of similar roadway in Xingdong Mine, a targeted control idea of surrounding rock zoning of roadway along goaf in deep isolated island was put forward, and then the joint control technical scheme of "integrated asymmetric arrangement of top and side angles of high-strength anchor cables and floor pressure relief groove" in the experimental section of No.11235 transport roadway was determined, and the field industrial practice and field monitoring showed that the control effect of surrounding rock of roadway along goaf was good.