The fire occurred in the working face of Douerping Mine 22610 during the tectonic shutdown. After the fire area was sealed by water in the low area of the main and secondary roadways, the confined area became a high concentration gas reservoir, and the gas in the fire area was continuously sampled and tested through the construction of kilometer boreholes to meet the requirements of article 279 of the Coal Mine Safety Regulations, which confirmed that the fire area was extinguished. In order to ensure the safe discharge of high concentration gas after the fire area was opened and sealed, the press-in local fan combined with the gas real-time monitoring was used to lock the air discharge of the closed roadway in sections, which successfully controlled the high concentration gas to about 1.0% for safe discharge and restored the full negative pressure ventilation. The results showed that the fire zone information was correctly judged and the feasibility of the segmental air locking scheme was verified, which can provide reference for the fire zone opening and sealing and high concentration gas discharge work.